"It's the questions we can't answer that teach us the most. They teach us how to think. If you give a man an answer, all he gains is a little fact. But give him a question and he'll look for his own answers. "
Patrick Rothfuss - The Wise Man's Fear
PUBLICATIONS
2022
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Arad, E., Yosefi, G., Kolusheva, S., Bitton, R., Rapaport, H., & Jelinek, R. (2022). Native Glucagon Amyloids Catalyze Key Metabolic Reactions. ACS nano, 16(8), 12889-12899.
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Yekymov, E., Attia, D., Levi-Kalisman, Y., Bitton, R., & Yerushalmi-Rozen, R. (2022). Effects of non-ionic micelles on the acid-base equilibria of a weak polyelectrolyte. Polymers, 14(9), 1926.
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Golodnizky, D., Shmidov, Y., Bitton, R., Bernardes, C. E., & Davidovich-Pinhas, M. (2022). Isotropic liquid state of triacylglycerols. Journal of Molecular Liquids, 353, 118703.
DOI: 10.1016/j.molliq.2022.118703
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Yosefi, G., & Bitton, R. (2022). Hierarchical Membranes Self‐Assembled at the Interface between Peptides and Polymer Aqueous Solutions. Israel Journal of Chemistry, e202200008.
DOI: 10.1002/ijch.202200008
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Levi, T., Yosefi, G., Bitton, R., & Rapaport, H. (2022). Macroscopic membranes self‐assembled by alginate and a cationic and amphiphilic peptide for cell culture. Polymers for Advanced Technologies.
DOI: 10.1002/pat.5657
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Cohen, N., Attia, D., Levi‐Kalisman, Y., Bitton, R., & Yerushalmi‐Rozen, R. (2022). Emergent hybrid mesophases in ternary mixtures of cellulose nanocrystals‐Pluronic micelles‐water. Polymers for Advanced Technologies.
DOI: 10.1002/pat.5647
2021
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Collis, D. W., Yilmaz, G., Yuan, Y., Monaco, A., Ochbaum, G., Shi, Y., … & Azevedo, H. S. . Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions. RSC Chemical Biology, 2(2), 568-576. Apr DOI:10.1039/d0cb00223b (2021).
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Liberman, G. N., Ochbaum, G., Bitton, R., & Arad, S. M. Antimicrobial hydrogels composed of chitosan and sulfated polysaccharides of red microalgae. Polymer, 215, 123353. Feb DOI:10.1016/j.polymer.2020.123353 (2021).
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Goldberg, N., Shmidov, Y., Kryukov, O., Aranovich, D., Cohen, S., & Bitton, R. Effect of heparin and peptide conjugation on structure and functional properties of alginate in solutions and hydrogels. Materials Advances, 2(1), 440-447. Jan DOI: 10.1039/d0ma00669f (2021).
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Shahar, C., Tidhar, Y., Jung, Y., Weissman, H., Cohen, S. R., Bitton, R., … & Rybtchinski, B. Control over size, shape, and photonics of self-assembled organic nanocrystals. Beilstein journal of organic chemistry, 17(1), 42-51.
Jan DOI: 10.3762/bjoc.17.5 (2021).
2020
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Wang, Y., Li, Z., Shmidov, Y., Carrazzone, R. J., Bitton, R., & Matson, J. B. (2020). Crescent-Shaped Supramolecular Tetrapeptide Nanostructures. Journal of the American Chemical Society, 142(47), 20058-20065.
Nov DOI: 10.1021/jacs.0c09399 (2020).
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Yosefi G, Levi T, Rapaport H, Bitton R. Time matters for macroscopic membranes formed by alginate and cationic β-sheet peptides Soft matter. Aug DOI: 10.1039/d0sm01197e (2020).
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Wang, Y., An, Y., Shmidov Y., Bitton R., Deshmukh, S.A., and Matson J.B. A combined experimental and computational approach reveals how aromatic peptide amphiphiles self-assemble to form ion-conducting nanohelices Materials Chemistry Frontiers.
Aug DOI: 10.1039/D0QM00369G (2020).
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Afik, N., Yadgar, O., Volison-Klimentiev, A., Peretz-Damari, S., Ohayon-Lavi, A., Alatawna, A., Yosefi G, Bitton R., Fuchs N. & Negev, O. (2020). Sensing Exposure Time to Oxygen by Applying a Percolation-Induced Principle. Sensors.
Aug DOI: 10.3390/s20164465 (2020).
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Attia, D., Cohen, N., Ochbaum, G., Levi-Klansman, Y., Bitton, R., & Yerushalmi-Rozen, R. (2020). Nano-to-meso structure of cellulose nanocrystals phases in ethylene-glycol-water mixtures. Soft Matter. Jul DOI: 10.1039/D0SM01025A (2020).
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Shmidov Y., Zhu Y., Matson J.B., and Bitton R., Effect of Crosslinker Topology on Enzymatic Degradation of Hydrogels. Biomacromolecules Jul DOI: 10.1021/acs.biomac.0c00722 (2020).
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Yosefi G, Cohen‐Erez I, Nativ‐Roth E, Rapaport H, Bitton R. Spontaneous Alignment of Self‐Assembled Cationic and Amphiphilic β‐Sheet Peptides. Advanced Materials Interfaces.
Jun DOI: 10.1002/admi.202000332 (2020).
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Guy, O., Einat, C., Ronen, B., & Ronit, B. Effect of the C-terminal Amino Acid of the Peptide on the Structure and Mechanical Properties of Alginate-Peptide Hydrogels Across Length-Scales. Soft matter.
Jul DOI: 10.1039/d0sm00329h (2020).
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Liberman, GN., Ochbaum, G., Mejubovsky-Mikhelis, M., Bitton, R., Arad, S. Physico-chemical characteristics of the sulfated polysaccharides of the red microalgae Dixoniella grisea and Porphyridium aerugineum. International journal of Biological macromolecules.
Feb DOI: 10.1016/j.ijbiomac.2019.09.205 (2020).
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Cohen, N., Ochbaum, G., Levi-Kalisman, Y., Bitton, R.,Yerushalmi-Rozen, R Polymer-Induced Modification of Cellulose Nanocrystal Assemblies in Aqueous Suspensions ACS Applied polymer materials. Feb DOI: 10.1021/acsapm.9b01048 (2020).
2019
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Parisi, D., Ruan, Y., Ochbaum, G., Silmore, K. S., Cullari, L. L., Liu, C. Y., … & Vlassopoulos, D. (2019). Short and Soft: Multidomain Organization, Tunable Dynamics, and Jamming in Suspensions of Grafted Colloidal Cylinders with a Small Aspect Ratio. Langmuir, 35(52), 17103-17113.
DOI: 10.1021/acs.langmuir.9b03025 (2019).
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Shmidov, Y., Zhou, M. J., Yosefi, G., Bitton, R. & Matson, J. B. Hydrogels composed of hyaluronic acid and dendritic ELPs: hierarchical structure and physical properties. Soft Matter 15, 917-925.
DOI:10.1039/c8sm02450b (2019).
2018
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Weil, L. E., Shmidov, Y., Kublanovsky, M., Morgenstern, D., Feldman, M., Bitton, R. & Levy, D. Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6. Journal of Molecular Biology 430, 4359-4368.
DOI: 10.1016/j.jmb.2018.08.028 (2018).
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Wang, Y., Kaur, K., Scannelli, S. J., Bitton, R. & Matson, J. B. Self-Assembled Nanostructures Regulate H2S Release from Constitutionally Isomeric Peptides. Journal of the American Chemical Society 140, 14945-14951.
DOI: 10.1021/jacs.8b09320 (2018).
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Uebe, R., Keren-Khadmy, N., Zeytuni, N., Katzmann, E., Navon, Y., Davidov, G., Bitton, R., Plitzko, J. M., Schuler, D. & Zarivach, R. The dual role of MamB in magnetosome membrane assembly and magnetite biomineralization. Molecular Microbiology 107, 542-557.
DOI: 10.1111/mmi.13899 (2018).
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Ochbaum, G., Davidovich-Pinhas, M. & Bitton, R. Tuning the mechanical properties of alginate-peptide hydrogels. Soft Matter 14, 4364-4373.
DOI: 10.1039/c8sm00059j (2018).
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Nudelman, H., Gonzalez, T. P., Kolushiva, S., Widdrat, M., Reichel, V., Peigneux, A., Davidov, G., Bitton, R., Faivre, D., Jimenez-Lopez, C. & Zarivach, R. The importance of the helical structure of a MamC-derived magnetite-interacting peptide for its function in magnetite formation. Acta Crystallographica Section D-Structural Biology 74, 10-20.
DOI:10.1107/s2059798317017491 (2018).
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Green, H., Ochbaum, G., Gitelman-Povimonsky, A., Bitton, R. & Rapaport, H. RGD-presenting peptides in amphiphilic and anionic beta-sheet hydrogels for improved interactions with cells. Rsc Advances 8, 10072-10080.
DOI:10.1039/c7ra12503h (2018).
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Abehsera, S., Zaccai, S., Mittelman, B., Glazer, L., Weil, S., Khalaila, I., Davidov, G., Bitton, R., Zarivach, R., Li, S. H., Li, F. H., Xiang, J. H., Manor, R., Aflalo, E. D. & Sagi, A. CPAP3 proteins in the mineralized cuticle of a decapod crustacean. Scientific Reports 8.
DOI: 10.1038/s41598-018-20835-x (2018).
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Ochbaum, G., & Bitton, R. Ochbaum, G., & Bitton, R. (2018). Using small-angle X-ray scattering (SAXS) to study the structure of self-assembling biomaterials. In Self-assembling Biomaterials (pp. 291-304). Woodhead Publishing. DOI:10.1016/B978-0-08-102015-9.00015-0 (2018).
2017
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Zhou, M., Shmidov, Y., Matson, J. B. & Bitton, R. Multi-scale characterization of thermoresponsive dendritic elastin-like peptides. Colloids and Surfaces B-Biointerfaces 153, 141-151.
DOI:10.1016/j.colsurfb.2017.02.014 (2017).
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Shi, Y. J., Hu, Y., Ochbaum, G., Lin, R., Bitton, R., Cui, H. G. & Azevedo, H. S. Enzymatic activation of cell-penetrating peptides in self-assembled nanostructures triggers fibre-to-micelle morphological transition. Chemical Communications 53, 7037-7040.
DOI: 10.1039/c7cc03512h (2017).
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Ochbaum, G. & Bitton, R. Effect of peptide self-assembly on the rheological properties of alginate-peptide conjugates solutions. Polymer 108, 87-96.
DOI: 10.1016/j.polymer.2016.11.048 (2017).
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Greenwald, M. B. Y., Frusic-Zlotkin, M., Soroka, Y., Ben Sasson, S., Bitton, R., Bianco-Peled, H. & Kohen, R. Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System. Oxidative Medicine and Cellular Longevity.
DOI: 10.1155/2017/5205471 (2017).
2016
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Zha, R. H., Velichko, Y. S., Bitton, R. & Stupp, S. I. Molecular design for growth of supramolecular membranes with hierarchical structure. Soft Matter 12, 1401-1410, DOI: 10.1039/c5sm02381e (2016).
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Radoul, M., Lewin, L., Cohen, B., Oren, R., Popov, S., Davidov, G., Vandsburger, M. H., Harmelin, A., Bitton, R., Greneche, J. M., Neeman, M. & Zarivach, R. Genetic manipulation of iron biomineralization enhances MR relaxivity in a ferritin-M6A chimeric complex. Scientific Reports 6.
DOI: 10.1038/srep26550 (2016).
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Navon, Y., Zhou, M. J., Matson, J. B. & Bitton, R. Dendritic Elastin-like Peptides: The Effect of Branching on Thermoresponsiveness. Biomacromolecules 17, 262-270.
DOI: 10.1021/acs.biomac.5b01371 (2016).
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Navon, Y. & Bitton, R. Elastin-Like Peptides (ELPs) - Building Blocks for Stimuli-Responsive Self-Assembled Materials. Israel Journal of Chemistry 56, 581-589, DOI: 10.1002/ijch.201500016 (2016).
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Liberman, G. N., Ochbaum, G., Arad, S. & Bitton, R. The sulfated polysaccharide from a marine red microalga as a platform for the incorporation of zinc ions. Carbohydrate Polymers 152, 658-664.
DOI: 10.1016/j.carbpol.2016.07.025 (2016).
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Bernstein-Levi, O., Ochbaum, G. & Bitton, R. The effect of covalently linked RGD peptide on the conformation of polysaccharides in aqueous solutions. Colloids and Surfaces B-Biointerfaces 137, 214-220.
DOI: 10.1016/j.colsurfb.2015.06.042 (2016).
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Barber-Zucker, S., Uebe, R., Davidov, G., Navon, Y., Sherf, D., Chill, J. H., Kass, I., Bitton, R., Schuler, D. & Zarivach, R. Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance. Scientific Reports 6.
DOI: 10.1038/srep31933 (2016).
2015
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Matson, J. B., Navon, Y., Bitton, R. & Stupp, S. I. Light-Controlled Hierarchical Self-Assembly of Polyelectrolytes and Supramolecular Polymers. Acs Macro Letters 4, 43-47.
DOI:10.1021/mz500677q (2015).
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Inostroza-Brito, K. E., Collin, E., Siton-Mendelson, O., Smith, K. H., Monge-Marcet, A., Ferreira, D. S., Rodriguez, R. P., Alonso, M., Rodriguez-Cabello, J. C., Reis, R. L., Sagues, F., Botto, L., Bitton, R., Azevedo, H. S. & Mata, A. Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein-peptide system. Nature Chemistry 7, 897-904.
DOI: 10.1038/nchem.2349 (2015).
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Greenwald, M. B. Y., Frusic-Zlotkin, M., Soroka, Y., Ben Sasson, S., Bianco-Peled, H., Bitton, R. & Kohen, R. Nitroxide delivery system for Nrf2 activation and skin protection. European Journal of Pharmaceutics and Biopharmaceutics 94, 123-134.
DOI:10.1016/j.ejpb.2015.05.008 (2015).
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Davidov, G., Müller, F. D., Baumgartner, J., Bitton, R., Faivre, D., Schüler, D., & Zarivach, R. (2015). Crystal structure of the magnetobacterial protein MtxA C-terminal domain reveals a new sequence-structure relationship. Frontiers in molecular biosciences, 2, 25.
DOI: 10.3389/fmolb.2015.00025 (2015).
2014
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Zeytuni, N., Uebe, R., Maes, M., Davidov, G., Baram, M., Raschdorf, O., Nadav-Tsubery, M., Kolusheva, S., Bitton, R., Goobes, G., Friedler, A., Miller, Y., Schuler, D. & Zarivach, R. Cation Diffusion Facilitators Transport Initiation and Regulation Is Mediated by Cation Induced Conformational Changes of the Cytoplasmic Domain. Plos One 9.
DOI: 10.1371/journal.pone.0092141 (2014).
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de la Rica, R., Chow, L. W., Horejs, C. M., Mazo, M., Chiappini, C., Pashuck, E. T., Bitton, R. & Stevens, M. M. A designer peptide as a template for growing Au nanoclusters. Chemical Communications.
DOI:10.1039/c4cc03240c (2014).
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Bitton, R., Chow, L. W., Zha, R. H., Velichko, Y. S., Pashuck, E. T. & Stupp, S. I. Electrostatic Control of Structure in Self-Assembled Membranes. Small 10, 500-505.
DOI:10.1002/smll.201300254 (2014).
2013
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Stupp, S. I., Zha, R. H., Palmer, L. C., Cui, H. G. & Bitton, R. Self-assembly of biomolecular soft matter. Faraday Discussions 166, 9-30.
DOI: 10.1039/c3fd00120b (2013).
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Guttman, C., Davidov, G., Yahalom, A., Shaked, H., Kolusheva, S., Bitton, R., Barber-Zucker, S., Chill, J. H. & Zarivach, R. BtcA, A Class IA Type III Chaperone, Interacts with the BteA N- Terminal Domain through a Globular/Non-Globular Mechanism. Plos One 8.
DOI:10.1371/journal.pone.0081557 (2013).
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Guttman, C., Davidov, G., Shaked, H., Kolusheva, S., Bitton, R., Ganguly, A., Miller, J. F., Chill, J. H. & Zarivach, R. Characterization of the N-Terminal Domain of BteA: A Bordetella Type III Secreted Cytotoxic Effector. Plos One 8.
DOI: 10.1371/journal.pone.0055650 (2013).
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Eliyahu-Gross, S. & Bitton, R. Environmentally responsive hydrogels with dynamically tunable properties as extracellular matrix mimetic. Reviews in Chemical Engineering 29, 159-168.
DOI: 10.1515/revce-2012-0022 (2013).
2012
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Velichko, Y. S., Mantei, J. R., Bitton, R., Carvajal, D., Shull, K. R. & Stupp, S. I. Electric Field Controlled Self-Assembly of Hierarchically Ordered Membranes. Advanced Functional Materials 22, 369-377.
DOI: 10.1002/adfm.201101538 (2012).
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Newcomb, C. J., Bitton, R., Velichko, Y. S., Snead, M. L. & Stupp, S. I. The Role of Nanoscale Architecture in Supramolecular Templating of Biomimetic Hydroxyapatite Mineralization. Small 8, 2195-2202.
DOI: 10.1002/smll.201102150 (2012).
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Matson, J. B., Newcomb, C. J., Bitton, R. & Stupp, S. I. Nanostructure-templated control of drug release from peptide amphiphile nanofiber gels. Soft Matter 8, 3586-3595.
DOI: 10.1039/c2sm07420f (2012).
2011
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Webber, M. J., Newcomb, C. J., Bitton, R. & Stupp, S. I. Switching of self-assembly in a peptide nanostructure with a specific enzyme. Soft Matter 7, 9665-9672.
DOI: 10.1039/c1sm05610g (2011).
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Goldberger, J. E., Berns, E. J., Bitton, R., Newcomb, C. J. & Stupp, S. I. Electrostatic Control of Bioactivity. Angewandte Chemie-International Edition 50, 6292-6295.
DOI: 10.1002/anie.201100202 (2011).
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Chow, L. W., Bitton, R., Webber, M. J., Carvajal, D., Shull, K. R., Sharma, A. K. & Stupp, S. I. A bioactive self-assembled membrane to promote angiogenesis. Biomaterials 32, 1574-1582.
DOI: 10.1016/j.biomaterials.2010.10.048 (2011).
2010
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Zhang, S. M., Greenfield, M. A., Mata, A., Palmer, L. C., Bitton, R., Mantei, J. R., Aparicio, C., de la Cruz, M. O. & Stupp, S. I. A self-assembly pathway to aligned monodomain gels. Nature Materials 9, 594-601.
DOI: 10.1038/nmat2778 (2010).
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Tu, R. S., Marullo, R., Pynn, R., Bitton, R., Bianco-Peled, H. & Tirrell, M. V. Cooperative DNA binding and assembly by a bZip peptide-amphiphile. Soft Matter 6, 1035-1044.
DOI: 10.1039/b922295b (2010).
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Carvajal, D., Bitton, R., Mantei, J. R., Velichko, Y. S., Stupp, S. I. & Shull, K. R. Physical properties of hierarchically ordered self-assembled planar and spherical membranes. Soft Matter 6, 1816-1823.
DOI: 10.1039/b923903k (2010).
2009
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Ruthstein, S., Raitsimring, A. M., Bitton, R., Frydman, V., Godt, A. & Goldfarb, D. Distribution of guest molecules in Pluronic micelles studied by double electron electron spin resonance and small angle X-ray scattering. Physical Chemistry Chemical Physics 11, 148-160.
DOI: 10.1039/b812475b (2009).
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Bitton, R., Josef, E., Shimshelashvilli, I., Shapira, K., Seliktar, D. & Bianco-Peled, H. Phloroglucinol-based biomimetic adhesives for medical applications. Acta Biomaterialia 5, 1582-1587.
DOI: 10.1016/j.actbio.2008.10.004 (2009).
2008
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Bitton, R. & Bianco-Peled, H. Novel biomimetic adhesives based on algae glue. Macromolecular Bioscience 8, 393-400.
DOI: 10.1002/mabi.200700239 (2008).
2007
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Bitton, R., Berglin, M., Elwing, H., Colin, C., Delage, L., Potin, P. & Bianco-Peled, H. The influence of halide-mediated oxiodation on algae-born adhesives. Macromolecular Bioscience 7, 1280-1289.
DOI: 10.1002/mabi.200700099 (2007).
2006
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Bitton, R., Ben-Yehuda, M., Davidovich, M., Balazs, Y., Potin, P., Delage, L., Colin, C. & Bianco-Peled, H. Structure of algal-born phenolic polymeric adhesives. Macromolecular Bioscience 6, 737-746.
DOI: 10.1002/mabi.200600073 (2006).