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"It's the questions we can't answer that teach us the most. They teach us how to think. If you give a man an answer, all he gains is a little fact. But give him a question and he'll look for his own answers. "

Patrick Rothfuss - The Wise Man's Fear

PUBLICATIONS

2022

  • Arad, E., Yosefi, G., Kolusheva, S., Bitton, R., Rapaport, H., & Jelinek, R. (2022). Native Glucagon Amyloids Catalyze Key Metabolic Reactions. ACS nano, 16(8), 12889-12899.

  • Yekymov, E., Attia, D., Levi-Kalisman, Y., Bitton, R., & Yerushalmi-Rozen, R. (2022). Effects of non-ionic micelles on the acid-base equilibria of a weak polyelectrolyte. Polymers, 14(9), 1926.

  • ‏Golodnizky, D., Shmidov, Y., Bitton, R., Bernardes, C. E., & Davidovich-Pinhas, M. (2022). Isotropic liquid state of triacylglycerols. Journal of Molecular Liquids, 353, 118703.
    DOI: 10.1016/j.molliq.2022.118703

  • Yosefi, G., & Bitton, R. (2022). Hierarchical Membranes Self‐Assembled at the Interface between Peptides and Polymer Aqueous Solutions. Israel Journal of Chemistry, e202200008.
    DOI: 10.1002/ijch.202200008

  • Levi, T., Yosefi, G., Bitton, R., & Rapaport, H. (2022). Macroscopic membranes self‐assembled by alginate and a cationic and amphiphilic peptide for cell culture. Polymers for Advanced Technologies.
    DOI: 10.1002/pat.5657

  • Cohen, N., Attia, D., Levi‐Kalisman, Y., Bitton, R., & Yerushalmi‐Rozen, R. (2022). Emergent hybrid mesophases in ternary mixtures of cellulose nanocrystals‐Pluronic micelles‐water. Polymers for Advanced Technologies.
    DOI: 10.1002/pat.5647‏‏

 

 

2021

  • Collis, D. W., Yilmaz, G., Yuan, Y., Monaco, A., Ochbaum, G., Shi, Y., … & Azevedo, H. S. . Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions. RSC Chemical Biology, 2(2), 568-576. Apr DOI:10.1039/d0cb00223b (2021).

  • Liberman, G. N., Ochbaum, G., Bitton, R., & Arad, S. M. Antimicrobial hydrogels composed of chitosan and sulfated polysaccharides of red microalgae. Polymer, 215, 123353. Feb DOI:10.1016/j.polymer.2020.123353 (2021).

  • Goldberg, N., Shmidov, Y., Kryukov, O., Aranovich, D., Cohen, S., & Bitton, R. Effect of heparin and peptide conjugation on structure and functional properties of alginate in solutions and hydrogels. Materials Advances, 2(1), 440-447.          Jan DOI: 10.1039/d0ma00669f (2021).

  • Shahar, C., Tidhar, Y., Jung, Y., Weissman, H., Cohen, S. R., Bitton, R., … & Rybtchinski, B. Control over size, shape, and photonics of self-assembled organic nanocrystals. Beilstein journal of organic chemistry, 17(1), 42-51.

      Jan DOI: 10.3762/bjoc.17.5 (2021).

2020​

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  • Wang, Y., Li, Z., Shmidov, Y., Carrazzone, R. J., Bitton, R., & Matson, J. B. (2020). Crescent-Shaped Supramolecular Tetrapeptide Nanostructures. Journal of the American Chemical Society, 142(47), 20058-20065. 

      Nov DOI: 10.1021/jacs.0c09399 (2020).

  • Yosefi G, Levi T, Rapaport H, Bitton R. Time matters for macroscopic membranes formed by alginate and cationic β-sheet peptides Soft matter.                    Aug DOI: 10.1039/d0sm01197e (2020).

  • Wang, Y., An, Y., Shmidov Y., Bitton R., Deshmukh, S.A., and Matson J.B. A combined experimental and computational approach reveals how aromatic peptide amphiphiles self-assemble to form ion-conducting nanohelices Materials Chemistry Frontiers.                                                                                             

      Aug DOI: 10.1039/D0QM00369G (2020).

  • Afik, N., Yadgar, O., Volison-Klimentiev, A., Peretz-Damari, S., Ohayon-Lavi, A., Alatawna, A., Yosefi G, Bitton R.,  Fuchs N. & Negev, O. (2020). Sensing Exposure Time to Oxygen by Applying a Percolation-Induced Principle. Sensors.              

      Aug DOI: 10.3390/s20164465 (2020).

  • Attia, D., Cohen, N., Ochbaum, G., Levi-Klansman, Y., Bitton, R., & Yerushalmi-Rozen, R. (2020). Nano-to-meso structure of cellulose nanocrystals phases in ethylene-glycol-water mixtures. Soft Matter.                                                          Jul ‏DOI: 10.1039/D0SM01025A (2020).

  • Shmidov Y., Zhu Y., Matson J.B., and Bitton R., Effect of Crosslinker Topology on Enzymatic Degradation of Hydrogels. Biomacromolecules                                     Jul DOI: 10.1021/acs.biomac.0c00722 (2020).

  • Yosefi G, Cohen‐Erez I, Nativ‐Roth E, Rapaport H, Bitton R. Spontaneous Alignment of Self‐Assembled Cationic and Amphiphilic β‐Sheet Peptides. Advanced Materials Interfaces.                                                                              

      Jun DOI: 10.1002/admi.202000332 (2020).

  • Guy, O., Einat, C., Ronen, B., & Ronit, B. Effect of the C-terminal Amino Acid of the Peptide on the Structure and Mechanical Properties of Alginate-Peptide Hydrogels Across Length-Scales. Soft matter.‏                                                                 

      Jul DOI: 10.1039/d0sm00329h (2020).

  • Liberman, GN., Ochbaum, G., Mejubovsky-Mikhelis, M., Bitton, R., Arad, S. Physico-chemical characteristics of the sulfated polysaccharides of the red microalgae Dixoniella grisea and Porphyridium aerugineum. International journal of Biological macromolecules.                                                                               

      Feb DOI: 10.1016/j.ijbiomac.2019.09.205 (2020).

  • Cohen, N., Ochbaum, G., Levi-Kalisman, Y., Bitton, R.,Yerushalmi-Rozen, R Polymer-Induced Modification of Cellulose Nanocrystal Assemblies in Aqueous Suspensions ACS Applied polymer materials.                                                        Feb DOI: 10.1021/acsapm.9b01048 (2020).

2019​

  • Parisi, D., Ruan, Y., Ochbaum, G., Silmore, K. S., Cullari, L. L., Liu, C. Y., … & Vlassopoulos, D. (2019). Short and Soft: Multidomain Organization, Tunable Dynamics, and Jamming in Suspensions of Grafted Colloidal Cylinders with a Small Aspect Ratio. Langmuir, 35(52), 17103-17113.                                                   

      DOI: 10.1021/acs.langmuir.9b03025 (2019).

  • Shmidov, Y., Zhou, M. J., Yosefi, G., Bitton, R. & Matson, J. B. Hydrogels composed of hyaluronic acid and dendritic ELPs: hierarchical structure and physical properties. Soft Matter 15, 917-925.

      DOI:10.1039/c8sm02450b (2019).

2018​

  • Weil, L. E., Shmidov, Y., Kublanovsky, M., Morgenstern, D., Feldman, M., Bitton, R. & Levy, D. Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6. Journal of Molecular Biology 430, 4359-4368.

      DOI: 10.1016/j.jmb.2018.08.028 (2018).

  •  Wang, Y., Kaur, K., Scannelli, S. J., Bitton, R. & Matson, J. B. Self-Assembled Nanostructures Regulate H2S Release from Constitutionally Isomeric Peptides. Journal of the American Chemical Society 140, 14945-14951.

      DOI: 10.1021/jacs.8b09320 (2018).

  • Uebe, R., Keren-Khadmy, N., Zeytuni, N., Katzmann, E., Navon, Y., Davidov, G., Bitton, R., Plitzko, J. M., Schuler, D. & Zarivach, R. The dual role of MamB in magnetosome membrane assembly and magnetite biomineralization. Molecular Microbiology 107, 542-557.

      DOI: 10.1111/mmi.13899 (2018).

  • Ochbaum, G., Davidovich-Pinhas, M. & Bitton, R. Tuning the mechanical properties of alginate-peptide hydrogels. Soft Matter 14, 4364-4373.

      DOI: 10.1039/c8sm00059j (2018).

  • Nudelman, H., Gonzalez, T. P., Kolushiva, S., Widdrat, M., Reichel, V., Peigneux, A., Davidov, G., Bitton, R., Faivre, D., Jimenez-Lopez, C. & Zarivach, R. The importance of the helical structure of a MamC-derived magnetite-interacting peptide for its function in magnetite formation. Acta Crystallographica Section D-Structural Biology 74, 10-20. 

      DOI:10.1107/s2059798317017491 (2018).

  • Green, H., Ochbaum, G., Gitelman-Povimonsky, A., Bitton, R. & Rapaport, H. RGD-presenting peptides in amphiphilic and anionic beta-sheet hydrogels for improved interactions with cells. Rsc Advances 8, 10072-10080.

      DOI:10.1039/c7ra12503h (2018).

  • Abehsera, S., Zaccai, S., Mittelman, B., Glazer, L., Weil, S., Khalaila, I., Davidov, G., Bitton, R., Zarivach, R., Li, S. H., Li, F. H., Xiang, J. H., Manor, R., Aflalo, E. D. & Sagi, A. CPAP3 proteins in the mineralized cuticle of a decapod crustacean. Scientific Reports 8.

      DOI: 10.1038/s41598-018-20835-x (2018).

  • Ochbaum, G., & Bitton, R. Ochbaum, G., & Bitton, R. (2018). Using small-angle X-ray scattering (SAXS) to study the structure of self-assembling biomaterials. In Self-assembling Biomaterials (pp. 291-304). Woodhead Publishing.    DOI:10.1016/B978-0-08-102015-9.00015-0 (2018).

2017​

  • Zhou, M., Shmidov, Y., Matson, J. B. & Bitton, R. Multi-scale characterization of thermoresponsive dendritic elastin-like peptides. Colloids and Surfaces B-Biointerfaces 153, 141-151.

      DOI:10.1016/j.colsurfb.2017.02.014 (2017).

  • Shi, Y. J., Hu, Y., Ochbaum, G., Lin, R., Bitton, R., Cui, H. G. & Azevedo, H. S. Enzymatic activation of cell-penetrating peptides in self-assembled nanostructures triggers fibre-to-micelle morphological transition. Chemical Communications 53, 7037-7040.

      DOI: 10.1039/c7cc03512h (2017).

  • Ochbaum, G. & Bitton, R. Effect of peptide self-assembly on the rheological properties of alginate-peptide conjugates solutions. Polymer 108, 87-96.         

      DOI: 10.1016/j.polymer.2016.11.048 (2017).

  • Greenwald, M. B. Y., Frusic-Zlotkin, M., Soroka, Y., Ben Sasson, S., Bitton, R., Bianco-Peled, H. & Kohen, R. Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System. Oxidative Medicine and Cellular Longevity.

      DOI: 10.1155/2017/5205471 (2017).

2016​

  • Zha,  R. H., Velichko, Y. S., Bitton, R. & Stupp, S. I. Molecular design for growth of supramolecular membranes with hierarchical structure. Soft Matter 12, 1401-1410, DOI: 10.1039/c5sm02381e (2016).

  • Radoul, M., Lewin, L., Cohen, B., Oren, R., Popov, S., Davidov, G., Vandsburger, M. H., Harmelin, A., Bitton, R., Greneche, J. M., Neeman, M. & Zarivach, R. Genetic manipulation of iron biomineralization enhances MR relaxivity in a ferritin-M6A chimeric complex. Scientific Reports 6.

      DOI: 10.1038/srep26550 (2016).

  • Navon, Y., Zhou, M. J., Matson, J. B. & Bitton, R. Dendritic Elastin-like Peptides: The Effect of Branching on Thermoresponsiveness. Biomacromolecules 17, 262-270.

      DOI: 10.1021/acs.biomac.5b01371 (2016).

  • Navon, Y. & Bitton, R. Elastin-Like Peptides (ELPs) - Building Blocks for Stimuli-Responsive Self-Assembled Materials. Israel Journal of Chemistry 56, 581-589, DOI: 10.1002/ijch.201500016 (2016).

  • Liberman, G. N., Ochbaum, G., Arad, S. & Bitton, R. The sulfated polysaccharide from a marine red microalga as a platform for the incorporation of zinc ions. Carbohydrate Polymers 152, 658-664.

      DOI: 10.1016/j.carbpol.2016.07.025 (2016).

  • Bernstein-Levi, O., Ochbaum, G. & Bitton, R. The effect of covalently linked RGD peptide on the conformation of polysaccharides in aqueous solutions. Colloids and Surfaces B-Biointerfaces 137, 214-220.

      DOI: 10.1016/j.colsurfb.2015.06.042 (2016).

  • Barber-Zucker, S., Uebe, R., Davidov, G., Navon, Y., Sherf, D., Chill, J. H., Kass, I., Bitton, R., Schuler, D. & Zarivach, R. Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance. Scientific Reports 6.

      DOI: 10.1038/srep31933 (2016).

2015​

  • Matson, J. B., Navon, Y., Bitton, R. & Stupp, S. I. Light-Controlled Hierarchical Self-Assembly of Polyelectrolytes and Supramolecular Polymers. Acs Macro Letters 4, 43-47.

      DOI:10.1021/mz500677q (2015).

  • Inostroza-Brito, K. E., Collin, E., Siton-Mendelson, O., Smith, K. H., Monge-Marcet, A., Ferreira, D. S., Rodriguez, R. P., Alonso, M., Rodriguez-Cabello, J. C., Reis, R. L., Sagues, F., Botto, L., Bitton, R., Azevedo, H. S. & Mata, A. Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein-peptide system. Nature Chemistry 7, 897-904.

      DOI: 10.1038/nchem.2349 (2015).

  • Greenwald, M. B. Y., Frusic-Zlotkin, M., Soroka, Y., Ben Sasson, S., Bianco-Peled, H., Bitton, R. & Kohen, R. Nitroxide delivery system for Nrf2 activation and skin protection. European Journal of Pharmaceutics and Biopharmaceutics 94, 123-134.

      DOI:10.1016/j.ejpb.2015.05.008 (2015).

  • Davidov, G., Müller, F. D., Baumgartner, J., Bitton, R., Faivre, D., Schüler, D., & Zarivach, R. (2015). Crystal structure of the magnetobacterial protein MtxA C-terminal domain reveals a new sequence-structure relationship. Frontiers in molecular biosciences, 2, 25.

      DOI: 10.3389/fmolb.2015.00025 (2015).

2014​

  • Zeytuni, N., Uebe, R., Maes, M., Davidov, G., Baram, M., Raschdorf, O., Nadav-Tsubery, M., Kolusheva, S., Bitton, R., Goobes, G., Friedler, A., Miller, Y., Schuler, D. & Zarivach, R. Cation Diffusion Facilitators Transport Initiation and Regulation Is Mediated by Cation Induced Conformational Changes of the Cytoplasmic Domain. Plos One 9.

      DOI: 10.1371/journal.pone.0092141 (2014).

  • de la Rica, R., Chow, L. W., Horejs, C. M., Mazo, M., Chiappini, C., Pashuck, E. T., Bitton, R. & Stevens, M. M. A designer peptide as a template for growing Au nanoclusters. Chemical Communications.

      DOI:10.1039/c4cc03240c (2014).

  • Bitton, R., Chow, L. W., Zha, R. H., Velichko, Y. S., Pashuck, E. T. & Stupp, S. I. Electrostatic Control of Structure in Self-Assembled Membranes. Small 10, 500-505.

      DOI:10.1002/smll.201300254 (2014).

2013​

  • Stupp, S. I., Zha, R. H., Palmer, L. C., Cui, H. G. & Bitton, R. Self-assembly of biomolecular soft matter. Faraday Discussions 166, 9-30.

      DOI: 10.1039/c3fd00120b (2013).

  • Guttman, C., Davidov, G., Yahalom, A., Shaked, H., Kolusheva, S., Bitton, R., Barber-Zucker, S., Chill, J. H. & Zarivach, R. BtcA, A Class IA Type III Chaperone, Interacts with the BteA N- Terminal Domain through a Globular/Non-Globular Mechanism. Plos One 8. 

      DOI:10.1371/journal.pone.0081557 (2013).

  • Guttman, C., Davidov, G., Shaked, H., Kolusheva, S., Bitton, R., Ganguly, A., Miller, J. F., Chill, J. H. & Zarivach, R. Characterization of the N-Terminal Domain of BteA: A Bordetella Type III Secreted Cytotoxic Effector. Plos One 8.

      DOI: 10.1371/journal.pone.0055650 (2013).

  • Eliyahu-Gross, S. & Bitton, R. Environmentally responsive hydrogels with dynamically tunable properties as extracellular matrix mimetic. Reviews in Chemical Engineering 29, 159-168.

      DOI: 10.1515/revce-2012-0022 (2013).

2012​

  • Velichko, Y. S., Mantei, J. R., Bitton, R., Carvajal, D., Shull, K. R. & Stupp, S. I. Electric Field Controlled Self-Assembly of Hierarchically Ordered Membranes. Advanced Functional Materials 22, 369-377.

      DOI: 10.1002/adfm.201101538 (2012).

  • Newcomb, C. J., Bitton, R., Velichko, Y. S., Snead, M. L. & Stupp, S. I. The Role of Nanoscale Architecture in Supramolecular Templating of Biomimetic Hydroxyapatite Mineralization. Small 8, 2195-2202.

      DOI: 10.1002/smll.201102150 (2012).

  • Matson, J. B., Newcomb, C. J., Bitton, R. & Stupp, S. I. Nanostructure-templated control of drug release from peptide amphiphile nanofiber gels. Soft Matter 8, 3586-3595.

      DOI: 10.1039/c2sm07420f (2012).

2011​

  • Webber, M. J., Newcomb, C. J., Bitton, R. & Stupp, S. I. Switching of self-assembly in a peptide nanostructure with a specific enzyme. Soft Matter 7, 9665-9672.

      DOI: 10.1039/c1sm05610g (2011).

  • Goldberger, J. E., Berns, E. J., Bitton, R., Newcomb, C. J. & Stupp, S. I. Electrostatic Control of Bioactivity. Angewandte Chemie-International Edition 50, 6292-6295.

      DOI: 10.1002/anie.201100202 (2011).

  • Chow, L. W., Bitton, R., Webber, M. J., Carvajal, D., Shull, K. R., Sharma, A. K. & Stupp, S. I. A bioactive self-assembled membrane to promote angiogenesis. Biomaterials 32, 1574-1582.

      DOI: 10.1016/j.biomaterials.2010.10.048 (2011).

2010​

  • Zhang, S. M., Greenfield, M. A., Mata, A., Palmer, L. C., Bitton, R., Mantei, J. R., Aparicio, C., de la Cruz, M. O. & Stupp, S. I. A self-assembly pathway to aligned monodomain gels. Nature Materials 9, 594-601.

      DOI: 10.1038/nmat2778 (2010).

  • Tu, R. S., Marullo, R., Pynn, R., Bitton, R., Bianco-Peled, H. & Tirrell, M. V. Cooperative DNA binding and assembly by a bZip peptide-amphiphile. Soft Matter 6, 1035-1044.

      DOI: 10.1039/b922295b (2010).

  • Carvajal, D., Bitton, R., Mantei, J. R., Velichko, Y. S., Stupp, S. I. & Shull, K. R. Physical properties of hierarchically ordered self-assembled planar and spherical membranes. Soft Matter 6, 1816-1823.

      DOI: 10.1039/b923903k (2010).

2009​

  • Ruthstein, S., Raitsimring, A. M., Bitton, R., Frydman, V., Godt, A. & Goldfarb, D. Distribution of guest molecules in Pluronic micelles studied by double electron electron spin resonance and small angle X-ray scattering. Physical Chemistry Chemical Physics 11, 148-160.

      DOI: 10.1039/b812475b (2009).

  • Bitton, R., Josef, E., Shimshelashvilli, I., Shapira, K., Seliktar, D. & Bianco-Peled, H. Phloroglucinol-based biomimetic adhesives for medical applications. Acta Biomaterialia 5, 1582-1587.

      DOI: 10.1016/j.actbio.2008.10.004 (2009).

2008

  • Bitton, R. & Bianco-Peled, H. Novel biomimetic adhesives based on algae glue. Macromolecular Bioscience 8, 393-400.

      DOI: 10.1002/mabi.200700239 (2008).

2007​

  • Bitton, R., Berglin, M., Elwing, H., Colin, C., Delage, L., Potin, P. & Bianco-Peled, H. The influence of halide-mediated oxiodation on algae-born adhesives. Macromolecular Bioscience 7, 1280-1289.

      DOI: 10.1002/mabi.200700099 (2007).

2006​

  • Bitton, R., Ben-Yehuda, M., Davidovich, M., Balazs, Y., Potin, P., Delage, L., Colin, C. & Bianco-Peled, H. Structure of algal-born phenolic polymeric adhesives. Macromolecular Bioscience 6, 737-746.

      DOI: 10.1002/mabi.200600073 (2006).

Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions.jpg
Antimicrobial hydrogels composed of chitosan and sulfated polysaccharides of red microalga
Effect of heparin and peptide conjugation on structure and functional properties of algina
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